The series follows the story of Kafka Meta, a young man who works in a construction company and has always dreamed of becoming a member of the Defense Force, a group tasked with fighting against the kaiju. One day, Kafka is transformed into a giant monster, known as Kaiju No. 8, after being exposed to the DNA of a kaiju. This transformation sets Kafka on a journey to understand his new form and find a way to coexist with the other kaiju.